Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0006rdr9 | Gametes and Fertilisation | REDR2006

Development of the dominant follicle: mechanisms of selection and maintenance of oocyte quality

Webb R , Campbell BK

For a follicle to reach dominance, in mono-ovulatory species such as cattle, requires the integration of a number of processes involving both extra-ovarian signals and intra-follicular paracrine and autocrine regulators. Ovarian transplant studies in both cattle and sheep demonstrated that it takes approximately 4 months for primordial follicles to reach dominance. Gonadotrophins are not a prerequisite for the continued growth of pre-antral follicles, unlike antral folliclcs, ...

bp0002rdr10 | Inhibin | REDR1990

Inhibin and oestradiol in the control of FSH secretion in the sheep

Baird DT , Campbell BK , Mann GE , McNeilly AS

Summary. In the sheep both FSH and LH are necessary for development of large antral follicles. The secretion of FSH is controlled by the negative feedback effect of two ovarian hormones, oestradiol and inhibin, acting at the level of the anterior pituitary. Both are derived from the granulosa cells of large antral follicles which are present in sheep ovaries throughout the oestrous cycle. FSH stimulates growth and mitosis and so the fully differentiated granul...

bp0002rdr14 | Regulation of Folliculogenesis | REDR1990

Gonadotrophic control of follicle growth in the ewe

McNeilly AS , Picton HM , Campbell BK , Baird DT

Summary. Preovulatory follicle growth in the ewe is dependent on FSH although no precise relationship appears to exist between plasma concentrations of FSH and the number of preovulatory follicles which develop or ovulation rate. This may be related to a hitherto unrecognized influence of pulsatile LH on the growth of large follicles. Preovulatory follicle growth is dependent on the presence of basal amounts of LH, but pulsatile LH, while being essential to su...

bp0003rdr26 | Regulation of Gonadal Function | REDR1994

Control of antral follicle development and selection in sheep and cattle

Campbell BK , Scaramuzzi RJ , Webb R

The development of antral follicles in sheep and cattle is dependent on FSH, but large antral follicles can shift their gonadotrophic dependence from FSH to LH. The mechanisms that result in the selection of at least one ovulatory follicle from identical follicular cohorts, exposed to the same endocrine environment, still remain to be elucidated. The aim of this research was to extend in vitro results from the rodent to sheep and cattle and, using both in vivo</em...

bp0005rdr27 | Genes Controlling Reproductive Performance | REDR2002

Bone morphogenetic proteins and folliculogenesis: lessons from the Booroola mutation

Souza CJH , Campbell BK , McNeilly AS , Baird DT

The Booroola phenotype is associated with a point mutation in the kinase domain of the bone morphogenetic protein receptor 1B (BMPR1B), and is characterized by 'precocious' differentiation of ovarian follicles, leading to the production of large numbers of ovulatory follicles that are smaller in diameter than wild-type follicles. These smaller follicles attain differentiation markers, such as expression of mRNA for P450aromatase and inhibin-ßA subunit, granulosa c...

bp0008rdr25 | The Eric Lamming Memorial Session | REDR2014

Ovarian function in domestic ruminants: Mechanistic and translational aspects

Campbell BK , Hernandez-Medrano J , McNeilly AS , Webb R , Picton HM

Abstract. The purpose of this review is to illustrate the critical value of integration of both in vitro and whole animal approaches in order to make real progress in terms of understanding the underlying mechanisms controlling ovarian follicle development and also in utilising domestic ruminants as models for the human in the translational development of interventions to address infertility. In terms of mechanistic aspects, this review concentrates o...

bp0004rdr3 | Follicular Development | REDR1998

Molecular mechanisms regulating follicular recruitment and selection

Webb R , Campbell BK , Garverick HA , Gong JG , Gutierrez CG , Armstrong DG

Ovarian follicular growth and development is an integrated process encompassing both extraovarian signals, such as gonadotrophins and metabolic hormones, and intraovarian factors. Follicular development has been classified into gonadotrophin-independent and -dependent phases. In the latter, FSH provides the primary drive for follicular recruitment and LH is required for continued development of follicles to the preovulatory stage. A transient increase in circulating FSH preced...

bp0005rdr7 | Gamete-Somatic Cell Interactions | REDR2002

Mechanisms regulating follicular development and selection of the dominant follicle

Webb R , Nicholas B , Gong JG , Campbell BK , Gutierrez CG , Garverick HA , Armstrong DG

Reproductive function is an integrated process encompassing both extraovarian signals, such as gonadotrophins, and intrafollicular factors, such as locally produced growth factors. Initiation of primordial follicle growth and the early stages of folliculogenesis can occur without gonadotrophins. However, in vivo and in vitro studies indicate that FSH may stimulate the rate of preantral follicle growth and that it can take only 3 months for a primordial follic...

bp0005rdr32 | Ruminant Models for Human Clinical Medicine | REDR2002

Domestic ruminants as models for the elucidation of the mechanisms controlling ovarian follicle development in humans

Campbell BK , Souza C , Gong J , Webb R , Kendall N , Marsters P , Robinson G , Mitchell A , Telfer EE , Baird DT

It is necessary to understand the basic physiology underlying the complex process of folliculogenesis to address common causes of infertility and to devise innovative strategies to increase the efficiency of assisted reproduction technologies. Availability of suitable ovarian tissue is a major constraint to research in this area in humans, and monovulatory domestic ruminants represent a physiologically relevant model to elucidate basic mechanisms before more focused clinical i...