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Reproduction in Domestic Ruminants V

Reproduction in Domestic Ruminants V

Genes Controlling Reproductive Performance

bp0005rdr24 | Genes Controlling Reproductive Performance | REDR2002

The role of bone morphogenetic proteins in ovarian function

Shimasaki S , Moore RK , Erickson GF , Otsuka F

Bone morphogenetic proteins (BMPs) represent the largest subclass of growth factors in the transforming growth factor ß (TGF-ß) superfamily. BMPs have proven to be multifunctional regulators of a wide variety of biological processes in numerous types of cell and tissue. The role of inhibins, activins and TGF-ßs (which also belong to the TGF-ß superfamily) in reproduction has been studied extensively over the last 15 years. However, there were no reports on ...

bp0005rdr25 | Genes Controlling Reproductive Performance | REDR2002

Oocyte-derived growth factors and ovulation rate in sheep

McNatty KP , Juengel JL , Wilson T , Galloway SM , Davis GH , Hudson NL , Moeller CL , Cranfield M , Reader KL , Laitinen MPE , Groome NP , Sawyer HR , Ritvos O

The physiological mechanisms controlling ovulation rate in mammals involve a complex exchange of endocrine signals between the pituitary gland and the ovary, and a localized exchange of intraovarian hormones between the oocyte and its adjacent somatic cells. The discoveries in sheep of mutations in bone morphogenetic protein 15 (BMP15) and bone morphogenetic protein receptor type IB (BMPR-IB) together with recent findings on the physiological effects of growth differentiation ...

bp0005rdr26 | Genes Controlling Reproductive Performance | REDR2002

Prolificacy genes in sheep: the French genetic programmes

Mulsant P , Lecerf F , Fabre S , Bodin L , Thimonier J , Monget P , Lanneluc I , Monniaux D , Teyssier J , Elsen J-M

It has been demonstrated that variations in litter size or ovulation rate in different breeds of sheep can be associated with the segregation of several major genes. This set of natural mutants constitutes a valuable resource to determine key points in the biochemical pathways controlling the development of ovarian follicles. The French genetic programmes were devised to identify two of these genes: the Booroola (FecB) and Lacaune genes. The FecB pro...

bp0005rdr27 | Genes Controlling Reproductive Performance | REDR2002

Bone morphogenetic proteins and folliculogenesis: lessons from the Booroola mutation

Souza CJH , Campbell BK , McNeilly AS , Baird DT

The Booroola phenotype is associated with a point mutation in the kinase domain of the bone morphogenetic protein receptor 1B (BMPR1B), and is characterized by 'precocious' differentiation of ovarian follicles, leading to the production of large numbers of ovulatory follicles that are smaller in diameter than wild-type follicles. These smaller follicles attain differentiation markers, such as expression of mRNA for P450aromatase and inhibin-ßA subunit, granulosa c...