Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0002rdr4 | Maternal Recognition of Pregnancy | REDR1990

Physiological mechanisms of pregnancy recognition in ruminants

Bazer FW , Thatcher WW , Hansen PJ , Mirando MA , Ott TL , Plante C

Summary. Maternal recognition of pregnancy in sheep, cattle and goats involves physiological mechanisms that result in protection of corpora lutea from luteolysis by modification or inhibition of uterine production of luteolytic pulses of prostaglandin (PG) F-2α. Ovine, bovine and caprine luteal cells release oxytocin in a pulsatile manner during late dioestrus. Oxytocin then binds to its endometrial receptors and initiates luteolytic pulses of PGF-2&#945...

bp0004rdr22 | Embryonic Survival | REDR1998

Uterine differentiation as a foundation for subsequent fertility

Bartol FF , Wiley AA , Floyd JG , Ott TL , Bazer FW , Gray CA , Spencer TE

Uterine differentiation in cattle and sheep begins prenatally, but is completed postnatally. Mechanisms regulating this process are not well defined. However, studies of urogenital tract development in murine systems, particularly those involving tissue recombination and targeted gene mutation, indicate that the ideal uterine organizational programme evolves epigenetically through dynamic cell–cell and cell–matrix interactions that define the microenvironmental conte...

bp0018cpr37 | State-of-The Art in Conceptus-Uterus Interactions/Early Pregnancy Signaling | CPR2009

Conceptus-uterus interactions in pigs: endometrial gene expression in response to estrogens and interferons from conceptuses

Johnson G.A. , Bazer F.W. , Burghardt R.C. , Spencer T.E. , Wu G. , Bayless K.J.

This review highlights information on conceptus-uterus interactions in the pig with respect to uterine gene expression in response to estrogens and interferons (IF Ns) secreted from elongating conceptuses. Pig conceptuses release estrogens for pregnancy recognition, but also secrete IENs that do not appear to be antiluteolytic. Estrogens and IFNs induce expression of largely non-overlapping sets of genes, and evidence suggests that pig conceptuses orchestrate essential e...

bp0016cpr14 | Embryonic and Placental Development | CPR2001

Functional analysis of autocrine and paracrine signalling at the uterine–conceptus interface in pigs

Jaeger L. A. , Johnson L. A. , Ka H. , Gadow J. G. , Burghardt R. C. , Spencer T. E. , Bazer F.W.

The complexity of implantation necessitates intimate dialogue between conceptus and maternal cells, and precise coordination of maternal and conceptus signalling events. Maternal and conceptus-derived steroid hormones, growth factors and cytokines, as well as integrins and their ligands, have important and inter-related roles in mediating adhesion between apical aspects of conceptus trophectoderm and maternal uterine luminal epithelium that leads to formation of an epithelioch...