Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences
Previous issue | Volume 2 | REDR1990 | Next issue

Reproduction in Domestic Ruminants II

Reproduction in Domestic Ruminants II

Maternal Recognition of Pregnancy

bp0002editorial | Maternal Recognition of Pregnancy | REDR1990

Editorial: Reproduction in Domestic Ruminants

Webb R

As stated in the first Proceedings, the economically important domestic species have been the subject of ongoing reproductive research over many decades. The aims of researchers and clinicians have been directed at increasing fecundity and fertility, to manipulate reproduction for simpler management, to increase the genetic influence of selected individuals and importantly to improve animal welfare. A group of international researchers initiated the first symposium in Australi...

bp0002rdr1 | Maternal Recognition of Pregnancy | REDR1990

The polypeptides and genes for ovine and bovine trophoblast protein-1

Roberts RM , Klemann SW , Leaman DW , Bixby JA , JA Cross JC , Farin CE , Imakawa K , Hansen TR

Summary. Ovine and bovine trophoblast protein-1 (oTP-1 and bTP-1) have been strongly implicated as antiluteolytic agents and responsible for maternal recognition of pregnancy in sheep and cattle, respectively. Both are interferons (IFN) belonging to the IFN-α family, but their length (172 residues versus 166 for most IFN-α) places them in an unusual subclass (the IFN-αII). The various isoforms of oTP-1 and bTP-1 produced by trophoblas...

bp0002rdr2 | Maternal Recognition of Pregnancy | REDR1990

Molecular biology of trophoblast interferons and studies of their effects in vivo

Flint APF , Parkinson TJ , Stewart HJ , Vallet JL , Lamming GE

Summary. Southern blotting of bovine genomic DNA indicated the presence of at least 3 bovine tIFN genes. The full DNA sequence of one of these genes, thought to be expressed in trophoblast, has been determined, including 193 bp of 5' non-coding region. The inferred amino acid sequence of bovine tIFN is more similar to ovine tIFN (80%) than to bovine IFN-αII (70%). The 5' flanking sequence has some similarity with bovine IFN-&#94...

bp0002rdr3 | Maternal Recognition of Pregnancy | REDR1990

In-vitro studies of the effects of interferons on endometrial metabolism in sheep

Salamonsen LA , Cherny RA , Findlay JK

Summary. Primary cultures of ovine epithelial and stromal cells have been used to examine paracrine interactions between the endometrium and the preimplantation sheep blastocyst, and in particular the actions of the blastocyst α-interferon, ovine trophoblast protein-1 (oTP-1), on endometrial cell metabolism. The synthesis and secretion of several ‘pregnancy-related’ acidic proteins with molecular weights in the range 70 000–120 000 can be i...

bp0002rdr4 | Maternal Recognition of Pregnancy | REDR1990

Physiological mechanisms of pregnancy recognition in ruminants

Bazer FW , Thatcher WW , Hansen PJ , Mirando MA , Ott TL , Plante C

Summary. Maternal recognition of pregnancy in sheep, cattle and goats involves physiological mechanisms that result in protection of corpora lutea from luteolysis by modification or inhibition of uterine production of luteolytic pulses of prostaglandin (PG) F-2α. Ovine, bovine and caprine luteal cells release oxytocin in a pulsatile manner during late dioestrus. Oxytocin then binds to its endometrial receptors and initiates luteolytic pulses of PGF-2&#945...