bp0016cpr5 | OOcyte Development in vitro and in vivo | CPR2001
, Mandon-Pepin B.
, Cotinot C.
In mammals, testicular differentiation is initiated by SRY (the sex-determining
region of the Y chromosome) gene expression in Sertoli cell precursors,
followed by upregulation of the SOX9 gene (SRY-related HMG box gene 9).
Subsequently, differentiated testis produces two hormones that induce sexual
differentiation of the internal and external genital tract. Knowledge of the
molecular mechanisms involved in gonadal differentiation has increased
greatly over the past deca...