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Reproduction in Domestic Ruminants VI

bp0006rdr26 | Fetal Development | REDR2006

Flock differences in the impact of maternal dietary restriction on offspring growth and glucose tolerance in female offspring

Burt BE , Hess BW , Nathanielsz PW , Ford SP

Variable impacts of in-utero programming stimuli on postnatal offspring development suggest that genotype may play a role in this response. In this study, ewes from two flocks of similar breeding but adapted for 6–8 generations to one of two markedly different production environments were utilized (Baggs ewes - nomadic lifestyle and limited nutrition; UW ewes - sedentary lifestyle and adequate nutrition). Ewes from each flock were fed 50% (nutrient restricted) or 100...

bp0006rdr27 | Fetal Development | REDR2006

The developmental origins of health and disease: current theories and epigenetic mechanisms

Sinclair KD , Lea RG , Rees WD , Young LE

The retrospective cohort studies of David Barker and colleagues during the late 1980s established the principle that the incidence of certain adult diseases such as stroke, type 2 diabetes and dyslipidaemia may be linked to in utero development. Later termed the "Developmental Origins of Health and Disease (DOHaD)" hypothesis, there have been several more recent attempts to explain this phenomenon. Although a general conceptual framework has been established t...