REDR1990 Reproduction in Domestic Ruminants II Maternal Recognition of Pregnancy (5 abstracts)
The polypeptides and genes for ovine and bovine trophoblast protein-1
RM Roberts , SW Klemann , DW Leaman , JA Bixby , JC Cross , CE Farin , K Imakawa & TR Hansen
Departments of Animal Sciences and Biochemistry, University of Missouri, Columbia, MO 65211, USA
Summary. Ovine and bovine trophoblast protein-1 (oTP-1 and bTP-1) have been strongly implicated as antiluteolytic agents and responsible for maternal recognition of pregnancy in sheep and cattle, respectively. Both are interferons (IFN) belonging to the IFN-α family, but their length (172 residues versus 166 for most IFN-α) places them in an unusual subclass (the IFN-αII). The various isoforms of oTP-1 and bTP-1 produced by trophoblast tissue appear to arise in part from translation of multiple mRNAs which are themselves the products of distinct genes. These genes, like those for other IFN-α, are without introns. However, the genes for oTP-1 and bTP-1 form a distinct subgroup within the IFN-αII on the basis of their overall primary sequences and the high conservation of the 3'-untranslated ends of their transcription units. The bTP-1 genes also differ from the bovine IFN-αII in the organization of the promoter regions upstream from the transcription start site. Nevertheless, computer-aided analysis of the primary polypeptide sequences of oTP-1 and bTP-1 indicates that the molecules are likely to have approximately the same shapes and dimensions as all other IFN-α moleculcs. It remains to be determined whether they have unique biological properties which distinguish them from other IFN-α moleculcs.
Keywords: α-interferons; trophoblast; molecular cloning; sheep; cattle
© 1991 Journals of Reproduction & Fertility Ltd
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