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bp0017cpr6 | (1) | CPR2005

The role of intra-luteal factors in the control of the porcine corpus luteum

Gadsby J. , Rose L. , Sriperumbudur R. , Ge Z.

In this paper we review three intra-luteal factors and their roles in the corpus luteum (CL). Insulin-like growth factor (IGF)-I, together with its receptor and IGF-binding proteins (IGFBPs), represent an important control system in the CL. IGF-I is a product of small luteal cells and has steroidogenic (i.e. luteotrophic) actions on large luteal cells via the type I receptor, while IGFBPs (e.g. BP-2 and 3; small cells) generally inhibit IGF-Is actions. IGF-I is particula...