Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0004rdr25 | Embryonic Survival | REDR1998

Mechanism of action of interferon-tau in the uterus during early pregnancy

Hansen TR , Austin KJ , Perry DJ , Pru JK , Teixeira MG , Johnson GA

Early pregnancy is maintained in ruminants through the actions of conceptus-derived interferon (IFN)-tau on the endometrium. IFN-tau alters uterine release of PGF2α, which results in rescue of the corpus luteum and continued release of progesterone. The mechanism of action of IFN-tau includes inhibition of oestradiol receptors, consequent reduction in oxytocin receptors, activation of a cyclooxygenase inhibitor, and a shift in the PGs to favour PGE2 ...

bp0007rdr24 | The Ruminant Corpus Luteum | REDR2010

Endocrine actions of interferon-tau in ruminants

Hansen TR , Henkes LK , Ashley RL , Bott RC , Antoniazzi AQ , Han H

The ovine conceptus releases interferon-τ (IFNT), which prevents upregulation of the endometrial estrogen receptor (ESR1) and, consequently, oxytocin receptor (OXTR), thereby disrupting pulsatile release of prostaglandin F2α (PGF) in response to oxytocin. IFNT, through paracrine action on the endometrium, protects the corpus luteum (CL) during maternal recognition of pregnancy. Pregnancy also induces IFN stimulated genes (ISGs) in peripheral blood mononuclear cells (...

bp0002rdr1 | Maternal Recognition of Pregnancy | REDR1990

The polypeptides and genes for ovine and bovine trophoblast protein-1

Roberts RM , Klemann SW , Leaman DW , Bixby JA , JA Cross JC , Farin CE , Imakawa K , Hansen TR

Summary. Ovine and bovine trophoblast protein-1 (oTP-1 and bTP-1) have been strongly implicated as antiluteolytic agents and responsible for maternal recognition of pregnancy in sheep and cattle, respectively. Both are interferons (IFN) belonging to the IFN-α family, but their length (172 residues versus 166 for most IFN-α) places them in an unusual subclass (the IFN-αII). The various isoforms of oTP-1 and bTP-1 produced by trophoblas...