Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0010ised6 | (1) | ISED2019

Models of embryonic diapause in Carnivora

Murphy BD , Fenelon JC

The phenomenon of obligate embryonic diapause, comprising developmental arrest at the blastocyst stage, has been recognized to occur in more than 60 species in three families in the Order Carnivora. The evolutionary advantage believed to be conferred by this trait is that it permits mating and parturition to occur at the most favorable times of year for reproductive success and offspring survival. The carnivore blastocyst in diapause consists of hundreds of cells, configured i...

bp0010ised3 | (1) | ISED2019

Conserved mechanisms for putting pregnancy on hold in the mouse, mink and tammar wallaby

Fenelon JC , Shaw G , Renfree MB , Murphy BD

Embryonic diapause was first identified over 150 years ago, but many questions still remain about how the external and hormonal controls of embryonic diapause translate into how the uterus conveys information to the embryo. Current evidence suggests that the control of diapause is mediated by components of the uterine secretions. However, the identity of the essential signalling molecule(s) is unknown. The mouse (Mus musculus), the mink (Neovison vison) and t...

bp0010ised2 | (1) | ISED2019

A role for Msx genes in mammalian embryonic diapause

Cha J , Fenelon JC , Murphy BD , Shaw G , Renfree MB , Dey SK

Mammalian embryonic diapause is a reproductive phenomenon defined by the reversible arrest in blastocyst development and metabolic activity within the uterus which synchronously becomes quiescent to implantation. This natural strategy, evident in over 130 species across eight orders, can temporally uncouple conception from delivery until conditions are favorable for the survival of the mother and newborn. While the maternal endocrine milieu has been shown to be important for t...