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Bioscientifica Proceedings (2019) 1 REDRREDR19 | DOI: 10.1530/biosciprocs.1.019


Control of luteal function during early pregnancy in sheep

J Martal


Institul National de la Recherche Agronomique, Laboratoire de Physiologie de la Lactation, C.N.R.Z.-78350 Jouy-en-Josas, France

Summary. Prolactin and LH are required for the maintenance of normal luteal structures during early pregnancy in the ewe, whilst luteolysis, induced by prostaglandin F-2α is inhibited by the presence of the conceptus. The trophoblast also secretes a local anti-luteolytic factor, trophoblastin, which is most probably a protein because it is thermolabile and inactivated by pronase. It is soluble at pH 9.6 and can be separated on Ultrogel. Trophoblastin is present for a short time (12th-22nd day of pregnancy) but its effect may last several months.

© 1981 Journals of Reproduction & Fertility Ltd

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Reproductive Endocrinology of Domestic Ruminants

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