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bp0005rdr23 | Neuroendocrine Interactions | REDR2002

Origin of cerebrospinal fluid melatonin and possible function in the integration of photoperiod

Tricoire H , Møller M , Chemineau P , Malpaux B

Melatonin, which is synthesized at night by the pineal gland, is present in the cerebrospinal fluid (CSF), but its entry site and its role in this compartment are not known. Using several approaches, we tested the hypothesis that melatonin enters the CSF through the pineal recess, an evagination of the third ventricle. CSF melatonin concentrations are higher near the pineal gland than in the anterior part of the third ventricle, and decrease markedly (80%) after sealing of...