Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0007rdr8 | Assessing Gene Function in Ruminants | REDR2010

Putative role of cocaine- and amphetamine-regulated transcript (CARTPT) in dominant follicle selection in cattle

Smith GW , Sen A , Folger JK , Ireland JJ

The mechanisms regulating development of a single (dominant) follicle capable of ovulation during each follicular wave in cattle and atresia of remaining follicles (dominant follicle selection) are not well understood. FSH and IGF1 are known regulators of follicle growth and granulosa cell estradiol production during follicular waves. Recent evidence indicates cocaine and amphetamine regulated transcript (CARTPT), with intraovarian expression only in single-ovulating ...

bp0004rdr29 | Local Cellular and Tissue Communication | REDR1998

Regulation of ovarian extracellular matrix remodelling by metalloproteinases and their tissue inhibitors: effects on follicular development, ovulation and luteal function

Smith MF , Mclntush EW , Ricke WA , Kojima FN , Smith GW

In most organs, remodelling of tissues after morphogenesis is minimal; however, normal ovarian function depends upon cyclical remodelling of the extracellular matrix (ECM). The ECM has a profound effect on cellular functions and probably plays an important role in the processes of follicular development and atresia, ovulation, and development, maintenance and regression of corpora lutea. Matrix metalloproteinases (MMPs; collagenases, gelatinases, stromelysins and membrane-type...

bp0007rdr30 | Managing Fertility in Domestic Ruminants | REDR2010

Causes and consequences of the variation in the number of ovarian follicles in cattle

Evans ACO , Mossa F , Fair T , Lonergan P , Butler ST , Zielak-Steciwko AE , Smith GW , Jimenez-Krassel F , Folger JK , Ireland JLH , Ireland JJ

Summary. In cattle we have noted that the antral follicle count (AFC, follicles ≥3 mm in diameter) varies greatly among animals (from 5 to 50), is repeatable within animals, and is highly correlated with the total number of healthy follicles in ovaries. Also, animals with low AFC have higher serum concentrations of FSH and LH, but lower concentrations of Anti-Mullerian Hormone, progesterone and androgens than animals with high AFC. We have investigated t...