Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0003rdr30 | Environmental and Metabolic Interactions | REDR1994

Endocrine basis for puberty in heifers and ewes

Kinder JE , Bergfeld EGM , Wehrman ME , Peters KE , Kojima FN

Maturation processes that culminate in puberty and sexual maturity are initiated before birth, continue through prepuberty (> 50 days before puberty) and peripuberty (50 days before puberty) and are completed early after puberty. The hypothalamus is the primary site of change during transition to sexual maturity. Maturation of the hypothalamus results from decreased negative feedback of oestradiol that leads to increased frequency of release of LH pulses. Increased tonic r...

bp0004rdr29 | Local Cellular and Tissue Communication | REDR1998

Regulation of ovarian extracellular matrix remodelling by metalloproteinases and their tissue inhibitors: effects on follicular development, ovulation and luteal function

Smith MF , Mclntush EW , Ricke WA , Kojima FN , Smith GW

In most organs, remodelling of tissues after morphogenesis is minimal; however, normal ovarian function depends upon cyclical remodelling of the extracellular matrix (ECM). The ECM has a profound effect on cellular functions and probably plays an important role in the processes of follicular development and atresia, ovulation, and development, maintenance and regression of corpora lutea. Matrix metalloproteinases (MMPs; collagenases, gelatinases, stromelysins and membrane-type...