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bp0008rdr21 | Oocyte and Follicle | REDR2014

Theca cells and the regulation of ovarian androgen production

Knight Phil G , Glister Claire

Summary. Theca cells are essential for female reproduction being the source of androgens that are precursors for follicular oestrogen synthesis and also signal through androgen receptors (AR) in the ovary and elsewhere. Theca cells arise from mesenchymal cells around the secondary follicle stage. Their recruitment, proliferation and cytodifferentiation are influenced, directly or indirectly, by paracrine signals from granulosa cells and oocyte although uncerta...