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bp0004rdr34 | Reproductive Technology | REDR1998

Activation of primordial follicles in vitro

Fortune JE , Kito S , Byrd DD

The resting pool of primordial follicles in mammalian ovaries is a potential resource for the genetic manipulation of domestic animals, the preservation of endangered species, and the amelioration of some forms of infertility in humans. Exploitation of this large reservoir of follicles depends on the development of methods for activating primordial follicles to begin growth in vitro and of methods for sustaining follicular growth to the stage at which oocytes are capa...