Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0004rdr22 | Embryonic Survival | REDR1998

Uterine differentiation as a foundation for subsequent fertility

Bartol FF , Wiley AA , Floyd JG , Ott TL , Bazer FW , Gray CA , Spencer TE

Uterine differentiation in cattle and sheep begins prenatally, but is completed postnatally. Mechanisms regulating this process are not well defined. However, studies of urogenital tract development in murine systems, particularly those involving tissue recombination and targeted gene mutation, indicate that the ideal uterine organizational programme evolves epigenetically through dynamic cell–cell and cell–matrix interactions that define the microenvironmental conte...