Searchable, peer-reviewed, open-access proceedings from bioscience and biomedical conferences

bp0005rdr14 | Pre-natal Programming of Lifetime Productivity and Health | REDR2002

Ruminant models of prenatal growth restriction

Anthony RV , Scheaffer AN , Wright CD , Regnault TRH

Intrauterine growth restriction (IUGR) is a significant health issue that not only affects infant mortality and morbidity, but may also predispose individuals to coronary heart disease, diabetes, hypertension and stroke as adults. The majority of IUGR pregnancies in humans are characterized by asymmetric fetal growth, resulting from inadequate nutrient transfer to the fetus. Furthermore, most of these pregnancies involve functional placental insufficiency, and may also show al...

bp0003rdr7 | Maternal-Embryo Interactions | REDR1994

The growth hormone/prolactin gene family in ruminant placentae

Anthony RV , Liang R , Kayl EP , Pratt SL

Ruminant placentae produce at least two distinct subclasses of the growth hormone/prolactin gene family, the placental lactogens and prolactin-related proteins. Placental lactogens have been purified from cattle, goat and sheep placentae, and the amino acid sequences of bovine and ovine placental lactogen are known. Bovine and ovine placental lactogens are structurally more similar to prolactin than they are to growth hormone. In addition, six unique mRNAs have been described ...

bp0007rdr9 | Assessing Gene Function in Ruminants | REDR2010

Assessing gene function in the ruminant placenta

Anthony RV , Cantlon JD , Gates KC , Purcell SH , Clay CM

The placenta provides the means for nutrient transfer from the mother to the fetus, waste transfer from the fetus to the mother, protection of the fetus from the maternal immune system, and is an active endocrine organ. While many placental functions have been defined and investigated, assessing the function of specific genes expressed by the placenta has been problematic, since classical ablation-replacement methods are not feasible with the placenta. The pregnant sheep has b...