Bioscientifica Proceedings

The hypothalamic GnRH pulse generator that regulates intermittent GnRH discharge into the pituitary portal circulation and thereby modulates pulsatile secretion of LH has been recognized as a key determinant of the reproductive function in mammals. Thus, various internal, as well as external, factors first modify the electrical activity of the GnRH pulse generator, which then alters the pulsatile pattern of gonadotrophin secretion and eventually influences reproductive functio...